Stem Cell Research

Why access to research should be democratized ?

Growth factors are indispensable for maintaining stem cell viability, proliferation, and differentiation. Fibroblast Growth Factor 2 (FGF-2) is critical for the self-renewal of human pluripotent stem cells, while Insulin-like Growth Factor 1 (IGF-1) plays a key role in enhancing mesenchymal stem cell expansion and promoting survival. Additionally, Vascular Endothelial Growth Factor (VEGF) is essential for directing stem cell differentiation into vascular lineages, impacting tissue engineering and regenerative therapies. Despite their fundamental role, the high cost of these recombinant proteins often forces labs to limit experimental scope or seek suboptimal alternatives.

Overcoming Financial Barriers in Stem Cell Research:

Stem cell research is driving breakthroughs in regenerative medicine, disease modeling, and drug development. However, financial constraints remain one of the biggest obstacles for researchers worldwide.

High costs for essential bioreagents, particularly recombinant proteins and growth factors, significantly limit access to advanced stem cell studies, slowing down scientific progress and restricting innovation to well-funded institutions.

FGFs play a crucial role in various cellular processes, such as proliferation, survival, differentiation, and migration, making them essential for embryonic development and the maintenance of adult tissue homeostasis.

FGF-2 sustains pluripotency while also guiding tissue differentiation including neural progenitor cells and chondrogenesis.

IGF signaling is crucial for regulating cell proliferation, differentiation, motility, development, and metabolism.

In stem cells, IGF-1 plays a key role in promoting self-renewal and enhancing survival by activating pathways that support growth and resistance to apoptosis. Additionally, IGF-1 influences lineage commitment, guiding stem cells toward specific cell fates including osteogenic and adipogenic.

VEGF signaling drives cell proliferation, survival, and migration, playing a crucial role in vasculogenesis, angiogenesis, development, and wound healing.

In organoids, VEGF promotes vascular network development by stimulating endothelial cell organization and integration, enabling efficient nutrient and oxygen exchange.

At Core Bio, we address this challenge by leveraging plant-based bioproduction to drastically reduce the cost of high-purity growth factors—making them more accessible without compromising quality. By breaking down financial barriers, we enable researchers worldwide to accelerate discoveries, expand experimental possibilities, and drive the next generation of stem cell therapies.

Products

  • rhFGF-2 (PL1-50, PL1-1000), RUO grade.

  • rFGF-2 TOP® (PL-50, PL-100), RUO grade.

  • rIGF-1 LR3 (OL11-50, OL11-1000), RUO grade.

  • rhEGF (OL3-50, OL3-1000), RUO grade.

  • rhVEGF (OL13-50, OL13-1000), RUO grade.

  • rhKGF (OL14-50, 0L14-1000), RUO grade.

  • rhAlbumin (OL7-1G, OL7-10G, OL7-100G), RUO grade.

  • rhTransferrin (OL12-1G, OL12-10G, 9L12-100G), RUO grade.

Core Research

Animal-free RUO proteins for stem cell culture processes

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